DNase I levels in JIA – influence of anti-TNF (etanercept) therapy
نویسندگان
چکیده
Methods The study was performed in 25 JIA patients who donated paired serum samples prior and one year after continous etanercept therapy. Basic clinical data (six core set variables defined in ACR PEDI outcome score) were recorded along with alkalyne DnaseI serum levels using the method where acid soluble nucleotides are determined spectrophotometrically at 260 nm. Treatment schedule of etanercept was 0, 4 mg/kg body weight subcutaneously twice weekly.
منابع مشابه
DNase I levels and disease outcome in JIA patients treated with etanercept
Methods The study was performed in 25 JIA patients who donated paired serum samples prior and one year after continous etanercept therapy. Basic clinical data (six core set variables defined in ACR PEDI outcome score) were recorded along with alkalyne DNase I serum levels using the method where acid soluble nucleotides are determined spectrophotometrically at 260 nm. Treatment schedule of etane...
متن کاملEfficacy of a second TNF blocker, when the first one failed, in patients with juvenile idiopathic arthritis (JIA)
Results Out of 60 JIA patients enrolled, 40 (37 f, 3 m) were evaluated: 10 systemic arthritis, 2 persistent oligoarthritis, 11 extended oligoarthritis, 9 RF negative polyarthritis, 4 RF positive polyarthritis, 1 ERA (enthesitis related arthritis), 3 psoriatic arthritis. With a standard Chi square model, we didn't find a significant difference in the ACR and DAS response rates between the first ...
متن کاملSalivary antioxidants and metalloproteinases in juvenile idiopathic arthritis.
Juvenile idiopathic arthritis (JIA) is the most common autoimmune inflammatory disease in children; joint inflammation is the hallmark of the disease. Thirty-five children with JIA were studied, of whom 26 had active disease and 14 were receiving anti-TNF therapy (5 with Infliximab, 9 with Etanercept). Sixteen healthy controls also were studied. Saliva samples were obtained for analysis of anti...
متن کاملEffects of anti-TNF therapy on ophtalmological complications in children with rheumatic diseases
Results Among 54 children treated with anti-TNF therapy at our Division during 2009. – 2013. period, 10 were detected with ophtalmologycal complications (8 girls, 2 boys), 8 with JIA, 1 with JDM and 1 with sarcoidosis. Nine patients had chronic uveitis (JIA, sarcoidosis) and 1 had ...cotton wool“ retinal lesions accompanied with bilateral papilar oedema (JDM). Avarage time between the begining ...
متن کاملLipid Profiles Alter from Pro-Atherogenic into Less Atherogenic and Proinflammatory in Juvenile Idiopathic Arthritis Patients Responding to Anti TNF-α Treatment
OBJECTIVE Dyslipidemia with higher inflammatory states, disease activity, and longer disease duration in juvenile idiopathic arthritis (JIA) patients seemed to increase the risks of atherosclerosis. Tumor necrosis factor- α (TNF-α) receptor blocking agent etanercept has been proven to be effective in JIA. However, data about the correlation of anti-inflammatory treatment on lipid profiles and a...
متن کامل